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PDGFRA antibody (C-Term)

PDGFRA Reactivity: Human, Mouse, Rat IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5611421
  • Target See all PDGFRA Antibodies
    PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
    Binding Specificity
    • 23
    • 16
    • 16
    • 15
    • 15
    • 11
    • 10
    • 9
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 243
    • 126
    • 73
    • 19
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 218
    • 40
    • 2
    • 1
    Rabbit
    Clonality
    • 211
    • 50
    Polyclonal
    Conjugate
    • 113
    • 20
    • 18
    • 14
    • 14
    • 12
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    This PDGFRA antibody is un-conjugated
    Application
    • 174
    • 110
    • 64
    • 54
    • 54
    • 39
    • 36
    • 23
    • 23
    • 13
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    Specific for PDGFR, alpha and does not react with PDGFR, beta. Cellular Localization Cell membrane.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Protein A Chromatography.
    Immunogen
    A synthetic peptide derived from the C-terminus of the precursor form of Human PDGFR alpha.
    Isotype
    IgG
    Top Product
    Discover our top product PDGFRA Primary Antibody
  • Application Notes
    ELISA. Immunohistochemistry on Paraffin Sections: Use Ab at 5-10 μg/mL for 30 min at RT. Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. Positive Control: Ovariancarcinoma.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 0.2 % BSA as stabilizer, before the addition of Glycerol to 40 %.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
    Alternative Name
    CD140a / PDGFRA (PDGFRA Products)
    Synonyms
    AI115593 antibody, CD140a antibody, Pdgfr-2 antibody, APDGFR antibody, PDGFACE antibody, CD140A antibody, PDGFR-2 antibody, PDGFR2 antibody, RHEPDGFRA antibody, PDGFR antibody, PDGFR-A antibody, platelet derived growth factor receptor alpha antibody, platelet derived growth factor receptor, alpha polypeptide antibody, platelet-derived growth factor receptor, alpha polypeptide L homeolog antibody, platelet-derived growth factor receptor, alpha polypeptide antibody, PDGFRA antibody, Pdgfra antibody, pdgfra.L antibody
    Background
    PDGFR (Platelet Derived Growth Factor Receptor) exhibits two different isoforms, alpha and beta coded by two different genes. They possess five immunoglobulin like domains that are involved in ligand binding. Two tyrosine kinase domains are separated by a kinase insert to which PI-3 kinase can bind. PDGF AA can bind autophosphorylate and activate only PDGFR, alpha while PDGF BB can bind and activate to both PDGFR, alpha and beta.Synonyms: Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, PDGF Receptor alpha, PDGF-R-alpha
    Gene ID
    5156
    NCBI Accession
    NP_006197
    UniProt
    P16234
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling
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