NR1H4 antibody (AA 363-472)

Catalog No. ABIN523347

Product Details anti-NR1H4 Antibody

Target: NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

Binding Specificity: AA 363-472

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NR1H4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purpose: Mouse monoclonal antibody raised against a partial recombinant NR1H4.

Sequence: TPMFSFYKSI GELKMTQEEY ALLTAIVILS PDRQYIKDRE AVEKLQEPLL DVLQKLCKIH QPENPQHFAC LLGRLTELRT FNHHHAEMLM SWRVNDHKFT PLLCEIWDVQ

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: NR1H4 (NP_005114, 363 a.a. ~ 472 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 1B10

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-NR1H4 antibody (ABIN523347)

Oehler, Volz, Bhadra, Kah, Allweiss, Giersch, Bierwolf, Riecken, Pollok, Lohse, Fehse, Petersen, Urban, Lütgehetmann, Heeren, Dandri: "Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism." in: Hepatology (Baltimore, Md.), Vol. 60, Issue 5, pp. 1483-93, (2014) (PubMed).

Chen, Song, Valanejad, Vasilenko, More, Qiu, Chen, Lai, Slitt, Stoner, Yan, Deng: "Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma." in: Hepatology (Baltimore, Md.), Vol. 57, Issue 4, pp. 1530-41, (2013) (PubMed).

Target Details for NR1H4

Target: NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

Alternative Name: NR1H4 (NR1H4 Products)

Synonyms: zgc:110190 antibody, zgc:92742 antibody, NR1H4 antibody, BAR antibody, FXR antibody, HRR-1 antibody, HRR1 antibody, RIP14 antibody, AI957360 antibody, Fxr antibody, Rxrip14 antibody, nuclear receptor subfamily 1, group H, member 5 S homeolog antibody, nuclear receptor subfamily 1, group H, member 4 antibody, nuclear receptor subfamily 1 group H member 4 antibody, nr1h5.S antibody, nr1h4 antibody, NR1H4 antibody, Nr1h4 antibody

Background: Full Gene Name: nuclear receptor subfamily 1, group H, member 4
Synonyms: BAR,FXR,HRR-1,HRR1,MGC163445,RIP14

Gene ID: 9971

NCBI Accession: NM_005123

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process