CDK1 antibody (N-Term)

Catalog No. ABIN504569

Product Details anti-CDK1 Antibody

Target: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EDYTKIEKIG EGTYGVVYKG RHKTTGQVVA MKKIRLESEE EGVPSTAIRE

Predicted Reactivity: Chicken: 100%

Characteristics: This is a rabbit polyclonal antibody against CDC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CDC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 297 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CDK1

Target: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Alternative Name: CDC2 (CDK1 Products)

Synonyms: CDC2 antibody, CDC28A antibody, P34CDC2 antibody, Cdc2 antibody, Cdc2a antibody, p34 antibody, cdc2 antibody, wu:fc30e01 antibody, zgc:92032 antibody, PSTAIR antibody, cdc-2 antibody, cdc2-a antibody, cdc28a antibody, cdc2x1.1 antibody, p34cdc2 antibody, xcdc2 antibody, 5363 antibody, CDCDm antibody, CDK1 antibody, CDK1/CDC2 antibody, CG5363 antibody, Cdk-1 antibody, Cdk1 antibody, Dcdc2 antibody, Dm cdc2 antibody, DmCdc2 antibody, DmCdk1 antibody, Dmcdc2 antibody, Dmel\\CG5363 antibody, cdc antibody, cdc2Dm antibody, cdk1 antibody, dCdk1 antibody, group 4 antibody, l(2)31Eh antibody, CDC2A antibody, CDC2AAT antibody, CDK2 antibody, CDKA1 antibody, CDKA;1 antibody, CYCLIN-DEPENDENT KINASE A;1 antibody, cell division control 2 antibody, cdc2-b antibody, cdc2a antibody, cdc2x1.2 antibody, POL3 antibody, pold antibody, cyclin dependent kinase 1 antibody, cyclin dependent kinase like 1 antibody, Cell division control protein 2 1 antibody, cyclin-dependent kinase 1 antibody, cyclin-dependent kinase 1 S homeolog antibody, Cyclin-dependent kinase 1 antibody, cell division control 2 antibody, cell division control protein2 homolog antibody, cyclin-dependent kinase 1 L homeolog antibody, polymerase (DNA directed), delta 1, catalytic subunit L homeolog antibody, cyclin-dependent protein kinase Cdk1/Cdc2 antibody, CDK1 antibody, CDKL1 antibody, POPTR_0004s14080g antibody, Cdk1 antibody, cdk1 antibody, cdk1.S antibody, CDC2 antibody, cdc2 antibody, cdk-1 antibody, cdk1.L antibody, pold1.L antibody

Background: The protein encoded by CDC2 is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
Alias Symbols: CDC28A, CDK1, DKFZp686L20222, MGC111195, CDC2, P34CDC2
Protein Interaction Partner: ABL1, SIRT1, CDC37, HUWE1, BTRC, UBC, HSP90AA1, HSPA4, HIST1H1A, GADD45A, CKS1B, USP16, Samhd1, UIMC1, SUMO2, CCNA2, STAU1, RNF2, CKS2, ZRANB2, CDKN1B, CDKN1A, CDK1, CCNB1, FBXO6, CCNB2, PKMYT1, SQSTM1, EGFR, PTMA, DCTN6, RGCC, BAG3, CDC25B, BCL2, TP53BP1
Protein Size: 297

Molecular Weight: 34 kDa

Gene ID: 983

NCBI Accession: NM_001786, NP_001777

UniProt: P06493

Pathways: Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Toll-Like Receptors Cascades, Synthesis of DNA