CEBPB antibody (N-Term)

Catalog No. ABIN504381

Product Details anti-CEBPB Antibody

Target: CEBPB (CCAAT/enhancer Binding Protein (C/EBP), beta (CEBPB))

Binding Specificity: N-Term

Reactivity: Human, Rat, Cow, Pig, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEBPB antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AIDFSPYLEP LGAPQAPAPA TATDTFEAAP PAPAPAPASS GQHHDFLSDL

Predicted Reactivity: Cow: 86%, Dog: 92%, Human: 100%, Pig: 100%, Rabbit: 100%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against CEBPB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CEBPB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 345 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CEBPB

Target: CEBPB (CCAAT/enhancer Binding Protein (C/EBP), beta (CEBPB))

Alternative Name: CEBPB (CEBPB Products)

Background: CEBPB is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: C/EBP-beta, CRP2, IL6DBP, LAP, MGC32080, NF-IL6, TCF5
Protein Interaction Partner: CEBPA, UBC, EGR1, EP300, TP63, RB1, RELA, DAXX, CASP8, CASP1, SMARCA2, HDAC1, SMARCC1, SMARCB1, SMARCA4, SMARCA5, TAF9, ELAVL1, SUMO2, TRIM28, CEBPB, ATF3, CARM1, GSK3B, SUMO1, KAT2A, HDAC9, KAT2B, NCOR2, NCOR1, STAT3, PPARG, NRF1, CREBBP, ATF2, EHMT2, SP
Protein Size: 345

Molecular Weight: 36 kDa

Gene ID: 1051

NCBI Accession: NM_005194, NP_005185

UniProt: P17676

Pathways: Interferon-gamma Pathway, Autophagy, Brown Fat Cell Differentiation