Aurora Kinase C antibody (Middle Region)

Catalog No. ABIN503487

Product Details anti-Aurora Kinase C Antibody

Target: Aurora Kinase C (AURKC)

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aurora Kinase C antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TYDEKVDLWC IGVLCYELLV GYPPFESASH SETYRRILKV DVRFPLSMPL

Predicted Reactivity: Cow: 93%, Dog: 93%, Goat: 79%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against AURKC. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human AURKC

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 309 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Aurora Kinase C antibody (ABIN503487)

Lee, Lim, Park, Lee, Han, Kim, Cheang, Lee, Lee, Ko, Jang, Kim, Miniaci, Bartsch, Kim, Bailey, Kandel, Kaang: "Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in Aplysia." in: Cell, Vol. 129, Issue 4, pp. 801-12, (2007) (PubMed).

Target Details for Aurora Kinase C

Target: Aurora Kinase C (AURKC)

Alternative Name: AURKC (AURKC Products)

Background: AURKC may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis.This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.
Alias Symbols: AIE2, AIK3, AurC, STK13, aurora-C, ARK3, SPGF5
Protein Interaction Partner: SRPK1, AURKB, HIST1H3A, INCENP, BIRC5, TACC2, UBC, HSP90AA1, BRCA1, LNX1, NEDD4L, NEDD4, CENPA,
Protein Size: 309

Molecular Weight: 34 kDa

Gene ID: 6795

NCBI Accession: NM_001015878, NP_001015878

UniProt: Q9UQB9

Pathways: Cell Division Cycle, Maintenance of Protein Location