PPP3CA antibody (Middle Region)

Catalog No. ABIN503232

Product Details anti-PPP3CA Antibody

Target: PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Horse, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP3CA antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LPSGVLSGGK QTLQSATVEA IEADEAIKGF SPQHKITSFE EAKGLDRINE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 91%

Characteristics: This is a rabbit polyclonal antibody against PPP3CA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PPP3CA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 521 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PPP3CA

Target: PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))

Alternative Name: PPP3CA (PPP3CA Products)

Background: PPP3CA belongs to the PPP phosphatase family, PP-2B subfamily. It is a calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. PPP3CA dephosphorylates HSPB1 and SSH1.
Alias Symbols: CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B
Protein Interaction Partner: C16orf74, PPP3R1, JUN, CEP76, MARCH7, VCP, TP53, UBC, SETSIP, P3H1, XPO5, MAT2B, TNPO3, PDIA6, VBP1, TSN, PPP2R2A, PFDN5, NRD1, NASP, TNPO1, HNRNPH1, ALY1, MAPK7, RCAN1, MRI1, RHOC, TRAF3, KCNIP3, PDE4D, PSMA6, PHLPP2, PTEN, AKT1, IRF2, GRB2, Fbxo32, MYOZ
Protein Size: 521

Molecular Weight: 59 kDa

Gene ID: 5530

NCBI Accession: NM_000944, NP_000935

UniProt: Q08209

Pathways: RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Synaptic Membrane, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling