SMC2 antibody (Middle Region)

Catalog No. ABIN502718

Product Details anti-SMC2 Antibody

Target: SMC2 (Structural Maintenance of Chromosomes 2 (SMC2))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Dog, Horse, Cow, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ATLAGQMMAC KNDISKAQTE AKQAQMKLKH AQQELKNKQA EVKKMDSGYR

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against SMC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SMC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1197 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMC2

Target: SMC2 (Structural Maintenance of Chromosomes 2 (SMC2))

Alternative Name: SMC2 (SMC2 Products)

Background: SMC2 belongs to the SMC family. It is a central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Alias Symbols: CAP-E, CAPE, FLJ10093, SMC2L1, hCAP-E
Protein Interaction Partner: UBC, RPA3, RPA2, RPA1, NCAPG, CCAR2, NCAPH, SSSCA1, SMC4, NCAPD2, PLEC, CDK9, FBXO6, EGFR, SOX2, GULP1, ABCC5, PAXIP1, SMC1A, UBD, NEDD8, SUMO2, NCAPG2, NCAPH2, NCAPD3, RAD21, LIG4, HIST2H3C, DISC1, TRAF3IP1, HIST2H2BE, HIST2H2AC, H2AFZ, MYC, tat, DNMT3B,
Protein Size: 1197

Molecular Weight: 136 kDa

Gene ID: 10592

NCBI Accession: NM_006444, NP_006435

UniProt: O95347