NFAT5 antibody (Middle Region)

Catalog No. ABIN501747

Product Details anti-NFAT5 Antibody

Target: NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Dog, Rabbit, Guinea Pig, Horse, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFAT5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PGQPQNEGQP PVTTLLSQQM PENSPLASSI NTNQNIEKID LLVSLQNQGN

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against NFAT5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NFAT5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1531 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NFAT5

Target: NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5))

Alternative Name: NFAT5 (NFAT5 Products)

Background: NFAT5 is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements.The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: KIAA0827, NF-AT5, NFATL1, NFATZ, OREBP, TONEBP
Protein Interaction Partner: gag-pol, SUMO2, TBC1D4, NFAT5, FOXP3,
Protein Size: 1531

Molecular Weight: 166 kDa

Gene ID: 10725

NCBI Accession: NM_006599, NP_006590

UniProt: O94916

Pathways: RTK Signaling, WNT Signaling