CCDC98 antibody (N-Term)

Catalog No. ABIN487439

Product Details anti-CCDC98 Antibody

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Binding Specificity: AA 1-313, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCDC98 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Specificity: This monoclonal antibody ABRA1-01 recognizes N-terminal part of ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: Protein FAM175A, ABRA1, Abraxas, Coiled-coil domain-containing protein 98, BRCA1-Acomplex subunit Abraxas

Purification: Protein A affinity chromatography

Immunogen: Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag

Clone: ABRA1-01

Isotype: IgG

Application Details

Application Notes: Immunoprecipitation. Western blot (reducing conditions).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH ~7.4, 15 mM Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing andthawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CCDC98

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Alternative Name: CCDC98 (FAM175A Products)

Background: ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.Synonyms: ABRA1, Abraxas, BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98, Protein FAM175A

Gene ID: 84142

UniProt: Q6UWZ7

Pathways: DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus