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CD3 antibody (APC)

CD3 Reactivity: Mouse FACS Host: Hamster Monoclonal 145-2C11 APC

Catalog No. ABIN487429

Datasheet as PDF

Target See all CD3 Antibodies

CD3
Reactivity
183

103

26

20

17

10

8

8

7

7

5

3

2

1
Mouse
Host
218

53

19

13

9

2
Hamster
Clonality
302

6

1
Monoclonal
Conjugate
96

39

32

23

22

11

9

8

6

5

5

5

4

4

3

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This CD3 antibody is conjugated to APC
Application
287

82

58

52

46

37

33

23

9

8

7

6

4

3

2

2

2

2

2

2

2

2

1

1

1
Flow Cytometry (FACS)

Specificity

This antibody reacts with mouse CD3 (epsilon subunit). It is commonly used as a phenotypic marker for mouse T cells.

Cross-Reactivity (Details)

Species reactivity (tested):Mouse

Characteristics

Synonyms: T3/Leu-4, T-cell surface glycoprotein CD3, T-cell surface antigen T3/Leu-4

Immunogen

Mouse BM10-37 cytotoxic T lymphocytes

Clone

145-2C11

Isotype

IgG

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Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Concentration

0.5 mg/mL

Buffer

Phosphate buffered saline (PBS) containing 15 mM sodium azide

Preservative

Sodium azide

Precaution of Use

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

4 °C

Storage Comment

Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.

Expiry Date

12 months
Target

CD3

Alternative Name

CD3 (CD3 Products)

Background

CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.Synonyms: T-cell surface antigen T3/Leu-4, T-cell surface glycoprotein CD3, T3/Leu-4

Gene ID

12501

UniProt

P22646

Pathways

TCR Signaling, Ubiquitin Proteasome Pathway