AKAP8 antibody (Middle Region)

Catalog No. ABIN486977

Product Details anti-AKAP8 Antibody

Target: AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))

Binding Specificity: Middle Region

Reactivity: Human, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKAP8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: YLKGEDPFTS ETVDPEMEGD DNLGGEDKKE TPEEVAADVL AEVITAAVRA

Predicted Reactivity: Cow: 85%, Dog: 85%, Horse: 92%, Human: 100%, Pig: 92%, Rabbit: 77%

Characteristics: This is a rabbit polyclonal antibody against AKAP8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human AKAP8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 692 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AKAP8

Target: AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))

Alternative Name: AKAP8 (AKAP8 Products)

Background: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP8 is a member of the AKAP family. It is located in the nucleus during interphase and is distinctly redistributed during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA.The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is distinctly redistributed during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AKAP95, DKFZp586B1222, AKAP-8, AKAP 95, AKAP-95
Protein Interaction Partner: SUMO2, UBC, RPA3, RPA2, RPA1, BMI1, RNF2, EZH2, HIPK4, HDAC11, CSNK2A1, MYC, ESR1, BARD1, LRRK2, CAND1, COPS5, CUL3, HNRNPA1, ELAVL1, Mis12, Aurkb, TADA2A, CASP3, DDX5, PRKAR2A, CCND1, RELA, CCND3, CCND2, MCM2, AMY1C, AMY1A,
Protein Size: 692

Molecular Weight: 76 kDa

Gene ID: 10270

NCBI Accession: NM_005858, NP_005849

UniProt: O43823

Pathways: SARS-CoV-2 Protein Interactome