SSRP1 antibody (Middle Region)
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- Target See all SSRP1 Antibodies
- SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SSRP1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- SSSNEGDSDR DEKKRKQLKK AKMAKDRKSR KKPVEVKKGK DPNAPKRPMS
- Predicted Reactivity
- Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 100%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against SSRP1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human SSRP1
- Top Product
- Discover our top product SSRP1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 709 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))
- Alternative Name
- SSRP1 (SSRP1 Products)
- Background
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SSRP1 is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. SSRP1 contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. It also functions as a co-activator of the transcriptional activator p63. The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FACT, FACT80, T160
Protein Interaction Partner: SUMO2, SUMO3, ATRX, UBC, EED, RNF2, SEC24C, CUL1, CSDE1, ATP6V1B2, DIABLO, SBNO1, PBDC1, EXOSC10, CSNK2A1, PNKP, VCAM1, SRPK1, ITGA4, FMNL1, SUPT16H, CENPA, LEO1, PAF1, PHGDH, SF3B1, NCSTN, RTF1, RBM14, SAP18, CTR9, S100A9, NOP2, HMGB1, HIST1H2BB, DHX9, C
Protein Size: 709 - Molecular Weight
- 81 kDa
- Gene ID
- 6749
- NCBI Accession
- NM_003146, NP_003137
- UniProt
- Q08945
- Pathways
- Chromatin Binding
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