Caspase 6 antibody (Cleaved-Asp162)

Catalog No. ABIN486701

Product Details anti-Caspase 6 Antibody

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Binding Specificity: AA 130-179, Cleaved-Asp162

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity:

Caspase 6 (Cleaved-Asp162) Antibody detects endogenous levels of fragment of activated Caspase 6 resulting from cleavage adjacent to Asp162.

Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 6.

Isotype: IgG

Application Details

Application Notes: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Comment:

Unigene-Number: Hs.654616 (NCBI Gene Symbol: CASP6)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable at -20°C for at least 1 year.

Expiry Date: 12 months

References for anti-Caspase 6 antibody (ABIN486701)

Yashiro, Qiu, Hasegawa, Zhang, Matsuzaki, Hirakawa: "An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells." in: British journal of cancer, (2011) (PubMed).

Target Details for Caspase 6

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Alternative Name: Caspase 6 (CASP6 Products)

Background:

Synonyms: ICE6, MCH2, apoptotic protease Mch-2, caspase-6

NCBI Gene Symbol: CASP6

Molecular Weight: 20 and 35 kDa

Gene ID: 839

OMIM: 601532

UniProt: P55212

Pathways: Apoptosis, Caspase Cascade in Apoptosis