Snurportin 1 antibody (Middle Region)

Catalog No. ABIN405342

Product Details anti-Snurportin 1 Antibody

Target: Snurportin 1 (SNUPN)

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Snurportin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GVAVPAGPLT TKPDYAGHQL QQIMEHKKSQ KEGMKEKLTH KASENGHYEL

Predicted Reactivity: Cow: 85%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SNUPN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SNUPN

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 360 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Snurportin 1

Target: Snurportin 1 (SNUPN)

Alternative Name: SNUPN (SNUPN Products)

Background: The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. SNUPN interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor.The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
Alias Symbols: KPNBL, RNUT1, Snurportin1
Protein Interaction Partner: UBC, HOTAIR, MEX3B, XPO1, GCNT3, RNF126, DBN1, RPL17, KPNB1, PAFAH1B2, TNNT3, PEX5, ENO2, RAN, DDX20, ZPR1, SNRPB, SMN1,
Protein Size: 360

Molecular Weight: 41 kDa

Gene ID: 10073

NCBI Accession: NM_005701, NP_005692

UniProt: O95149

Pathways: Ribonucleoprotein Complex Subunit Organization, Protein targeting to Nucleus