SRY antibody (Middle Region)
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- Target See all SRY Antibodies
- SRY (Sex Determining Region Y (SRY))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SRY antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- SEVQLDNRLY RDDCTKATHS RMEHQLGHLP PINAASSPQQ RDRYSHWTKL
- Predicted Reactivity
- Human: 100%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against SRY. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human SRY
- Top Product
- Discover our top product SRY Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 204 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SRY (Sex Determining Region Y (SRY))
- Alternative Name
- SRY (SRY Products)
- Background
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SRY is an intronless gene that encodes for a transcription factor, which is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor(TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome), translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome), translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: TDF, TDY, SRXX1, SRXY1
Protein Interaction Partner: Olig2, Utf1, Tcf12, Sp1, Pou3f3, Pax3, Jun, Hhex, Egr2, Dlx5, Cebpa, WDR5, SMAD3, HDAC3, KPNB1, EP300, Xpo4, ZNF208, SLC9A3R2, AR,
Protein Size: 204 - Molecular Weight
- 24 kDa
- Gene ID
- 6736
- NCBI Accession
- NM_003140, NP_003131
- UniProt
- Q05066
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