SRY antibody (Middle Region)

Catalog No. ABIN404966

Product Details anti-SRY Antibody

Target: SRY (Sex Determining Region Y (SRY))

Binding Specificity: Middle Region

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRY antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SEVQLDNRLY RDDCTKATHS RMEHQLGHLP PINAASSPQQ RDRYSHWTKL

Predicted Reactivity: Human: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SRY. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SRY

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 204 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SRY

Target: SRY (Sex Determining Region Y (SRY))

Alternative Name: SRY (SRY Products)

Background: SRY is an intronless gene that encodes for a transcription factor, which is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor(TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome), translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome), translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: TDF, TDY, SRXX1, SRXY1
Protein Interaction Partner: Olig2, Utf1, Tcf12, Sp1, Pou3f3, Pax3, Jun, Hhex, Egr2, Dlx5, Cebpa, WDR5, SMAD3, HDAC3, KPNB1, EP300, Xpo4, ZNF208, SLC9A3R2, AR,
Protein Size: 204

Molecular Weight: 24 kDa

Gene ID: 6736

NCBI Accession: NM_003140, NP_003131

UniProt: Q05066