BRCC3 antibody (N-Term)

Catalog No. ABIN400865

Product Details anti-BRCC3 Antibody

Target: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Binding Specificity: AA 1-316, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BRCC3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: The antibody recognizes human BRCC3 / BRCC36. Other species not tested.

Characteristics: Synonyms: BRCC36, C6.1A, CXorf53, Lys-63-specific deubiquitinase BRCC36, BRCA1-A complex subunitBRCC36, BRISC complex subunit BRCC36, BRCA1/BRCA2-containing complex subunit 3,BRCA1/BRCA2-containing complex subunit 36

Purification: Protein-G affinity chromatography

Immunogen: Recombinant BRCC36 (1-316 aa) purified from E. coli

Clone: AT3B1

Isotype: IgG1

Application Details

Application Notes: ELISA. Western blot (1: 1,000 - 1: 2,000). Immunohistochemistry on Paraffin Sections: (5 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for up to two weeks or (in aliquots) at -20 °C or -70 °Cfor longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for BRCC3

Target: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Alternative Name: BRCC3 (BRCC3 Products)

Background: BRCC3 (BRCC36, BRCA1/BRCA2-containing complex, subunit 36) is a holoenzyme complex containing BRCA1, BRCA2. BRCC36 is an ubiquitin E3 ligase complex that has a role in DNA repair and enhances cellular survival following DNA damage. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint.Synonyms: BRCA1-A complex subunit BRCC36, BRCA1/BRCA2-containing complex subunit 3, BRCA1/BRCA2-containing complex subunit 36, BRCC36, BRISC complex subunit BRCC36, C6.1A, CXorf53, Lys-63-specific deubiquitinase BRCC36

Gene ID: 79184

UniProt: P46736

Pathways: Positive Regulation of Response to DNA Damage Stimulus