TBK (pSer172) antibody

Catalog No. ABIN390010

Product Details

Target: TBK

Binding Specificity: pSer172

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Dot Blot (DB)

Predicted Reactivity: Zf, M, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TBK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S172 of human TBK.

Clone: RB16573

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References

Muvaffak, Pan, Yan, Fernandez, Lim, Dolinski, Nguyen, Strack, Wu, Chung, Zhang, Hulton, Ripley, Hirsch, Nagashima, Wong, Jánne, Seidel-Dugan, Zawel, Kirschmeier, Middleton, Morris, Wang: "Evaluating TBK1 as a therapeutic target in cancers with activated IRF3." in: Molecular cancer research : MCR, Vol. 12, Issue 7, pp. 1055-66, (2014) (PubMed).

Target Details

Target: TBK

Background: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

Molecular Weight: 83642

Gene ID: 29110

NCBI Accession: NP_037386

UniProt: Q9UHD2