MGLL antibody (Internal Region)

Catalog No. ABIN375108

Product Details anti-MGLL Antibody

Target: MGLL (Monoglyceride Lipase (MGLL))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This MGLL antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to Monoglyceride Lipase.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-QDLPHLVNADGQY, from the internal region (near NTerminus) of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/32000. Western Blot: 0.5 - 1.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-MGLL antibody (ABIN375108)

Blankman, Simon, Cravatt: "A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol." in: Chemistry & biology, Vol. 14, Issue 12, pp. 1347-56, (2007) (PubMed).

Target Details for MGLL

Target: MGLL (Monoglyceride Lipase (MGLL))

Alternative Name: Monoglyceride Lipase (MGLL Products)

Background: Endocannaboids such as arachidonoyl ethanolamide and 2-arachidonoyl glycerol function as short range modulators of cell and synaptic activity. Monoacylglycerol lipase hydrolyzes 2-arachidonoyl glycerol which terminates it's biological actions. Monoacylglycerol lipase also works consecutively with hormone sensitive lipase to mobilize fatty acids from triglyceride stores of adipocytes. Monoacylglycerol lipase is expressed in kidney, spleen, heart, liver, testis, stomach, brain and lung tissue, and adrenal gland. It is most abundantly expressed in skeletal muscle and adipose tissue.Synonyms: HU-K5, Lysophospholipase homolog, Lysophospholipase-like, MGL, MGLL

Gene ID: 11343, 9606

UniProt: Q99685

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Lipid Metabolism