CYLD antibody (Internal Region)

Catalog No. ABIN374832

Product Details anti-CYLD Antibody

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Binding Specificity: Internal Region

Reactivity: Mouse, Rat

Host: Goat

Clonality: Polyclonal

Conjugate: This CYLD antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to Cyld.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-DSQQSKSKNPWYIDE, from the internal region of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/32000. Western Blot: 0.5 - 1.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CYLD

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Alternative Name: CYLD (CYLD Products)

Background: Defects in CYLD are the cause of familial cylindromatosis (CYLD) also known as turban tumor syndrome or dermal eccrine cylindromatosis. CYLD is an autosomal dominant and highly tumor type-specific disorder. The tumors (known as cylindromas because of their characteristic microscopic architecture) are believed to arise from or recapitulate the appearance of the eccrine or apocrine cells of the skin that secrete sweat and scent respectively. Cylindromas arise predominantly in hairy parts of the body with approximately 90 % on the head and neck. The development of a confluent mass which may ulcerate or become infected has led to the designation "turban tumor syndrome". The skin tumors show differentiation in the direction of hair structures, hence the synonym trichoepithelioma. CYLD has deubiquitinating activity.Synonyms: CYLD, CYLD1, Deubiquitinating enzyme CYLD, EC=3.1.2.15, KIAA0849, Ubiquitin carboxyl-terminal hydrolase CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD

Gene ID: 1540

NCBI Accession: NP_001035814

UniProt: Q9NQC7

Pathways: Apoptosis, Activation of Innate immune Response