SNTA1 antibody (N-Term)

Catalog No. ABIN374379

Product Details anti-SNTA1 Antibody

Target: SNTA1 (Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig

Host: Goat

Clonality: Polyclonal

Conjugate: This SNTA1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: ASGRRAPRTG LLE-C

Specificity: This antibody detects Alpha-1-syntrophin (SNTA1) at N-term.

Cross-Reactivity (Details): Species reactivity (expected):Dog, Pig, Cow.
Species reactivity (tested):Human, Mouse, Rat.

Purification: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogen: Peptide from N Terminus of the protein sequence according to NP_003089.1 Genename: SNTA1

Application Details

Application Notes: Peptide ELISA: Detection limit dilution 1: 32000. Western Blot: 1-3 μg/mL. Approx 60 kDa band observed in Human Skeletal Muscle lysates(calculated MW of 53.0 kDa according to NP_003089.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.

Target Details for SNTA1

Target: SNTA1 (Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1))

Alternative Name: Syntrophin-1 / SNTA1 (SNTA1 Products)

Background: Syntrophins are structurally related proteins located at the neuromuscular synapse and play an important role in dystrophin associated protein (DAP) complex formation. To date there have been three distinct syntrophin isoforms discovered: alpha 1, beta 1, and beta 2. These proteins each contain a PDZ domain, a syntrophin-unique domain (SU), and three pleckstrin homology domains (PH1a,1b and 2). The PDZ domain has been shown to be responsible for binding syntrophin to nNOS and the DAP complex. This association results in localization of the nicotinic acetylcholine receptor to the cytoskeleton via the (S/T)XV C terminus.Synonyms: 59 kDa dystrophin-associated protein A1 acidic component 1, Alpha-1-syntrophin, Pro-TGF-alpha cytoplasmic domain-interacting protein 1, SNT1, TACIP1

Gene ID: 6640

NCBI Accession: NP_003089

UniProt: Q13424

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development