BCAP31 antibody (C-Term)

Catalog No. ABIN374194

Product Details anti-BCAP31 Antibody

Target: BCAP31 (B-Cell Receptor-Associated Protein 31 (BCAP31))

Binding Specificity: C-Term

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This BCAP31 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: C-QAAVDGPMDK KEE

Specificity: This antibody detects BCAP31 / BAP31 at C-term.

Purification: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogen: Peptide from C Terminus of the protein sequence according to NP_001132929.1, NP_005736.3, NP_001132913.1. Genename: BCAP31

Application Details

Application Notes: Peptide ELISA: Limit dilution 1: 4000. Western blot: 1-3 μg/mL. Approx 30 kDa band observed in Human Placenta and Brain lysate(predicted MW of 20 kDa according to NP_005736).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

Target Details for BCAP31

Target: BCAP31 (B-Cell Receptor-Associated Protein 31 (BCAP31))

Alternative Name: BCAP31 / BAP31 (BCAP31 Products)

Background: BAP31 (B Cell Receptor Associated Protein, 28 kDa) is a multiple membrane spanning protein of the endoplasmic reticulum. It has been shown to form both homo and hetero oligomers with the closely related BAP29, and is a potential apoptotic regulator as a predicted BCL2/BCLXL associated protein. In the C terminal domain of BAP31, there are two identical recognition sites for initiator Caspases 1 and 8 of the programmed death cascade. It is hypothesized that BAP31 plays a role in the transport of selected proteins to the Golgi apparatus. BAP31 has also been shown to control expression of CFTR (cystic fibrosis transmembrane conductance regulator). It is believed that interference with the expression or function of BAP31 in epithelial cells may be a way to circumvent the chloride channel defect in cystic fibrosis.Synonyms: 6C6-AG tumor-associated antigen, B-cell receptor-associated protein 31, BCR-associated protein Bap31, DXS1357E, Protein CDM, p28 Bap31

Gene ID: 10134

NCBI Accession: NP_001132929

UniProt: P51572

Pathways: Positive Regulation of Endopeptidase Activity