CD19 antibody
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- Target See all CD19 Antibodies
- CD19 (CD19 Molecule (CD19))
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Reactivity
- Mouse
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD19 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunoprecipitation (IP)
- Specificity
- This antibody is specific to CD19 B cell differentiation antigen (Mr. 95 kDa)
- Characteristics
- Synonyms: Leu-12, B-cell marker, Differentiation antigen CD19, B-lymphocyte surface antigen B4
- Purification
- Purified
- Immunogen
- CD19+ mouse pre-B cell line, 300. 19. (Ref. 1)
- Clone
- MB19-1
- Isotype
- IgA
- Top Product
- Discover our top product CD19 Primary Antibody
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- Application Notes
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Flow Cytometry. (Ref.1-3)Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.
- Storage
- 4 °C/-20 °C
- Storage Comment
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - Expiry Date
- 12 months
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- Target
- CD19 (CD19 Molecule (CD19))
- Alternative Name
- CD19 (CD19 Products)
- Background
- CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e., B220+/CD43+/HSA+) through fully differentiated B cell stages. (Ref.1-7) Terminally differentiated plasma cells do not express CD19.1 In humans, the CD19 Molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation. (Ref.3,4) All splenic and peritoneal IgM+ cells of both B-1 and B-2 lineages are CD19+, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites. (Ref.1,7) Recent studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow. (Ref.7)Synonyms: B-cell marker, B-lymphocyte surface antigen B4, Differentiation antigen CD19, Leu-12
- Gene ID
- 12478
- UniProt
- P25918
- Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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