Collagen Type IX antibody (Chain alpha 1)
Reactivity: Human
EIA, IHC (p), WB
Host: Rabbit
Polyclonal
unconjugated
2 images
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- Target See all Collagen Type IX products
- Collagen Type IX
- Binding Specificity
- Chain alpha 1
- Reactivity
- Human
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
- Specificity
- This antibody detects COL9A1 (Center). Predicted to cross react with Mouse (100 % Antigen Homology).
- Purification
- Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Immunogen
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human COL9A1.
- Isotype
- Ig Fraction
-
- Application Notes
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ELISA: 1/1,000. Western Blot: 1/50-1/100. Immunohistochemistry: 1/10-1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- PBS with 0.09 % (W/V) Sodium Azide as preservative.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- Target
- Collagen Type IX
- Abstract
- Collagen Type IX Products
- Background
- COL9A1 is one of the three alpha chains of type IX collagen, which is a minor (5-20 % ) collagen component of hyaline cartilage. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule,and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in the COL9A1 gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, and with Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects.Synonyms: COL9A1
- Molecular Weight
- 91855 Da
- Gene ID
- 1297, 9606
- UniProt
- P20849
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