Hepatitis B Virus Core Antigen (HBcAg) antibody

Catalog No. ABIN356457

Product Details

Target: Hepatitis B Virus Core Antigen (HBcAg)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purification: Ig Fraction

Immunogen: Purified hepatitis B core antigen.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry for Formalin-Fixed Paraffin Embedded (FFPE) Tissue Sections andFrozen Sections: Dilute 1/200-1/400 using polymer or streptavidin approx. biotin system for 30 mins at room temperature. Positive control: Human liver infected with hepatitis B virus.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 3.5 mg/mL

Buffer: 10 mM PO4, 150 mM NaCl, pH 7.4 containing 0.05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details

Target: Hepatitis B Virus Core Antigen (HBcAg)

Alternative Name: Hepatitis B Core Antigen / HBcAg (HBcAg Products)

Synonyms: precore; HBe antigen; PreC; HBeAg; precore protein; external core antigen; HBeAg; p25 antibody, C antibody

Target Type: Viral Protein

Background: Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection.Synonyms: HBV Capsid protein, HBV Core protein, p21.5