SLUG antibody (Middle Region)

Catalog No. ABIN318763

Product Details anti-SLUG Antibody

Target: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLUG antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: This antibody detects Slug, a member of the Snail family of zinc finger transcription factors, whose expression is induced by FGF, BMP, and TGF-beta. This antibody is not cross-reactive with Snail.

Purification: Purified

Immunogen: 13 amino acid peptide sequence near the centre of human Slug

Isotype: IgG

Application Details

Application Notes: Western Blot: 0.5 - 2.0g/mL, detects a band of approximately 30 kDa in 293 cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one month or at -20 °C for longer. Storage in frost-free freezers is not recommended. This product should be stored undiluted.

Target Details for SLUG

Target: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Alternative Name: SNAI2 / SLUG (SNAI2 Products)

Background: Slug is a 29kD transcriptional repressor, which functions by binding to E-box motifs and inhibiting gene expression by recruiting histone deacetylase-1 (HDAC-1). Slug controls the expression of a wide variety of genes including TP53, BRCA2, PUM and CDH1, and has important roles in apoptosis and epithelial-mesenchymal transition. It is also thought to function in neural crest development. Slug expression in breast, oesophageal, and colorectal carcinomas has been correlated with poor prognosis for survival.Synonyms: Neural crest transcription factor Slug, Protein snail homolog 2, SLUGH, Zinc finger protein SNAI2

Gene ID: 6591

NCBI Accession: NP_003059

UniProt: O43623