OPRK1 antibody

Catalog No. ABIN317765

Product Details anti-OPRK1 Antibody

Target: OPRK1 (Opioid Receptor, kappa 1 (OPRK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OPRK1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of KOR-1 protein.(region surrounding Arg361)

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1/1000-1/5000. Western blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-OPRK1 antibody (ABIN317765)

Niwa, Rowbotham, Lambert: "Evaluation of primary opioid receptor antibodies for use in western blotting." in: British journal of anaesthesia, Vol. 108, Issue 3, pp. 530-2, (2012) (PubMed).

Target Details for OPRK1

Target: OPRK1 (Opioid Receptor, kappa 1 (OPRK1))

Alternative Name: kappa Opioid Receptor (OPRK1 Products)

Background: Opioid is the term used to designate a group of compounds that are opium-like in their properties. These drugs have effects on perception of pain, consciousness, motor control, mood, and autonomic function, and can induce physical dependence. Pharmacological studies suggested that there are at least 3 major classes of opioid receptors, designated delta, kappa, and mu. They differ in their affinity for various opioid ligands and in their cellular distribution. Studies of the receptors in the mouse and rat show that they are structurally related and are members of the family of 7 transmembrane-spanning G protein-coupled receptors. The kappa opiod receptor inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. It is the receptor for beta-endorphin.Synonyms: KOR-1, KOR1, OPRK, OPRK1

Molecular Weight: approx. 48 kDa

Gene ID: 4986

NCBI Accession: NP_000903

UniProt: P41145