SREBF1 antibody (Middle Region)
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- Target See all SREBF1 Antibodies
- SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Rat, Mouse, Cow, Goat, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SREBF1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- DAGSPFQSSP LSLGSRGSGS GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR
- Predicted Reactivity
- Cow: 88%, Goat: 88%, Horse: 80%, Human: 82%, Mouse: 93%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against SREBF1. It was validated on Western Blot and immunohistochemistry.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human SREBF1
- Top Product
- Discover our top product SREBF1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 1177 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
- Alternative Name
- SREBF1 (SREBF1 Products)
- Background
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SREBF1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: SREBP1, bHLHd1, SREBP-1c
Protein Interaction Partner: UBC, ERLIN2, FBXW7, SMARCD3, HSP90AA1, SUMO1, ATXN1L, INSIG2, SCAP, ATXN1, LMNA, INSIG1, EGF, SREBF2, SREBF1, ZBTB7A, ZBTB7C, SUMO2, MED6, MED13, MED12, MED24, MED26, MED17, MED23, MED14, USF1, MED1, GSK3B, CREBBP, CDK8, MED25, MED15, MED7, MED21, SIRT1,
Protein Size: 1177 - Molecular Weight
- 125 kDa
- Gene ID
- 6720
- NCBI Accession
- NM_001005291, NP_001005291
- UniProt
- P36956
- Pathways
- AMPK Signaling, Caspase Cascade in Apoptosis, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha
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