TYR antibody (Middle Region)

Catalog No. ABIN310580

Product Details anti-TYR Antibody

Target: TYR (Tyrosinase (TYR))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Pig, Dog, Goat, Horse, Sheep, Cow, Zebrafish (Danio rerio), Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYR antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CLSLTQYESG SMDKAANFSF RNTLEGFASP LTGIADASQS SMHNALHIYM

Predicted Reactivity: Cow: 86%, Dog: 100%, Goat: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against TYR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TYR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 529 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TYR

Target: TYR (Tyrosinase (TYR))

Alternative Name: TYR (TYR Products)

Background: TYR is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. It catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
Alias Symbols: OCA1A, OCAIA, CMM8, SHEP3
Protein Interaction Partner: SYVN1, UBC, TYRP1, RB1,
Protein Size: 529

Molecular Weight: 58 kDa

Gene ID: 7299

NCBI Accession: NM_000372, NP_000363

UniProt: P14679