Follistatin antibody (C-Term)

Catalog No. ABIN310314

Product Details anti-Follistatin Antibody

Target: Follistatin (FST)

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep, Cow, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Follistatin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SLCDELCPDS KSDEPVCASD NATYASECAM KEAACSSGVL LEVKHSGSCN

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against FST. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FST

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 317 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Follistatin

Target: Follistatin (FST)

Alternative Name: FST (FST Products)

Background: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release.Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
Alias Symbols: FS
Protein Interaction Partner: INHBA, BMPR2, BMPR1A, C8orf33, TK1, MEST, INHBE, INHA, FN1, BMP5, TXN,
Protein Size: 317

Molecular Weight: 35 kDa

Gene ID: 10468

NCBI Accession: NM_006350, NP_006341

UniProt: Q6FHE1

Pathways: Negative Regulation of Hormone Secretion