RGS4 antibody (C-Term)

Catalog No. ABIN309586

Product Details anti-RGS4 Antibody

Target: RGS4 (Regulator of G-Protein Signaling 4 (RGS4))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Sheep, Guinea Pig, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EAQKKIFNLM EKDSYRRFLK SRFYLDLVNP SSCGAEKQKG AKSSADCASL

Predicted Reactivity: Cow: 86%, Dog: 92%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 86%

Characteristics: This is a rabbit polyclonal antibody against RGS4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human RGS4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 205 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RGS4

Target: RGS4 (Regulator of G-Protein Signaling 4 (RGS4))

Alternative Name: RGS4 (RGS4 Products)

Background: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein negatively regulates signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm.Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37 % identical to RGS1 and 97 % identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm.
Alias Symbols: MGC2124, MGC60244, RGP4, SCZD9
Protein Interaction Partner: GABBR1, KRIT1, PLCB1, COPB2, GNAQ, COPB1, ERBB3, PTAFR, GNAI2, GNAO1, GNAI1, CALM1, GNAI3, GNAT1,
Protein Size: 205

Molecular Weight: 23 kDa

Gene ID: 5999

NCBI Accession: NM_005613, NP_005604

UniProt: P49798

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling