Endoglin antibody (FITC)

Catalog No. ABIN302199

Product Details anti-Endoglin Antibody (FITC)

Target: Endoglin (ENG)

Reactivity: Human, Pig

Host: Mouse

Clonality: Monoclonal

Conjugate: This Endoglin antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Specificity: This antibody recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.

Cross-Reactivity (Details): Species reactivity (tested):Human, Porcine.

Characteristics: Synonyms: ENG, END, HHT1, ORW, ORW1

Immunogen: Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA

Clone: MEM-229

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry analysis of human blood cells using 20 l reagent / 100 l of whole bloodor 10^6 cells in a suspension.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS, 15 mM Sodium Azide, 0.2 % (w/v) high-grade protease free BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Endoglin

Target: Endoglin (ENG)

Alternative Name: CD105 / Endoglin (ENG Products)

Background: CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbR-2 as a receptor for TGFb-1 and TGFb-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFb-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.Synonyms: END, ENG, HHT1, ORW, ORW1

UniProt: P17813