-
- Target See all IL-6 (IL6) Antibodies
- IL-6 (IL6) (Interleukin 6 (IL6))
-
Reactivity
- Rat
-
Host
- Goat
-
Clonality
- Polyclonal
-
Conjugate
- This IL-6 antibody is conjugated to Biotin
-
Application
- Flow Cytometry (FACS)
- Purification
- The antibody was purified by affinity chromatography.
- Clone
- Poly5177
- Top Product
- Discover our top product IL6 Primary Antibody
-
anti-Interleukin 6 (IL6) (AA 111-150) antibody
IL6 Reactivity: Human, Mouse, Rat, Rabbit, Cow WB, ELISA, FACS, IF (p), IHC (p), IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Interleukin 6 (IL6) antibodyIL6 Reactivity: Human ELISA, FACS, Func, ELISpot Host: Mouse Monoclonal B-E8 unconjugated
anti-Interleukin 6 (IL6) (AA 21-211) antibodyIL6 Reactivity: Rat WB, IHC, IP, ICC Host: Mouse Monoclonal C4 unconjugated
anti-Interleukin 6 (IL6) (AA 27-212) antibodyIL6 Reactivity: Rhesus Monkey WB, IHC, IP, ICC Host: Mouse Monoclonal 18# unconjugated
anti-Interleukin 6 (IL6) (AA 21-211) antibodyIL6 Reactivity: Rat WB, IHC, IP, IF/ICC Host: Mouse Monoclonal unconjugated
anti-Interleukin 6 (IL6) (AA 27-241) antibodyIL6 Reactivity: Rabbit WB, IHC, IP, ICC Host: Mouse Monoclonal C305 unconjugated
anti-Interleukin 6 (IL6) (AA 101-150) antibodyIL6 Reactivity: Mouse, Rat WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Interleukin 6 (IL6) (AA 25-211) antibodyIL6 Reactivity: Rat WB Host: Rabbit Polyclonal unconjugated
anti-Interleukin 6 (IL6) (AA 27-55) antibodyIL6 Reactivity: Human WB, ELISA, IHC, FACS Host: Rabbit Polyclonal unconjugated
anti-Interleukin 6 (IL6) (AA 29-212) antibodyIL6 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
-
- Target
- IL-6 (IL6) (Interleukin 6 (IL6))
- Alternative Name
- IL-6 (IL6 Products)
- Background
- Interleukin 6 (IL-6) is a prototypic member of the IL-6 superfamily of cytokines. IL-6 is secreted by a variety of lymphoid and non-lymphoid cells including T cells, B cells, monocytes, fibroblasts, hepatocytes, endothelial cells, keratinocytes, etc. Mature Rat IL-6 is a 187 aa residue protein. At the protein sequence level, there is approximately 39 % identity between rat and human IL-6, and 87 % identity between mouse and rat IL-6. The production of IL-6 can be induced by numerous signals such as mitogenic or antigenic stimulation, lipopolysaccharides, calcium ionophores, cytokines, and viruses. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R) and a subunit (gp130) that acts as the universal signal-transducing element for all IL-6 family cytokines. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. One of the most important mechanism is that IL-6 is a key factor that reciprocally regulates Th17 and Foxp3+ Treg differentiation by inhibition of TGF-β induced Foxp3 and induction of RORγt, a Th17 lineage-specific transcription factor. Elevated serum IL-6 levels have been observed in a number of pathological conditions, including bacterial and viral infections, trauma, autoimmune diseases, inflammations and malignancies.
- Pathways
- TLR Signaling, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome
-
You are here:
