JAG1 antibody

Catalog No. ABIN2664595

Product Details anti-JAG1 Antibody

Target: JAG1 (Jagged 1 (JAG1))

Reactivity: Mouse

Host: Armenian Hamster

Clonality: Monoclonal

Conjugate: This JAG1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Purification: The antibody was purified by affinity chromatography.

Clone: HMJ1-29

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for JAG1

Target: JAG1 (Jagged 1 (JAG1))

Alternative Name: CD339 (JAG1 Products)

Background: CD339, also known as Jagged 1, is a 135 kD type 1 transmembrane protein, with one DSL (Delta, Serrate, LagZ) domain, fifteen EGF-like domains, and one cysteine-rich region. Jagged 1 is expressed by many cell types including macrophages, subsets of dendritic cells, astrocytes, stromal, and epithelial cells. CD339 regulates cell fate decisions in various tissues, and has an important role in neurogenesis and development of the cardiovascular system. Studies suggest Jagged 1 is involved in Th2 polarization and Treg induction.

Pathways: Notch Signaling, Stem Cell Maintenance