ADAM10 antibody
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- Target See all ADAM10 Antibodies
- ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This ADAM10 antibody is un-conjugated
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Application
- Intracellular Flow Cytometry (ICFC)
- Purification
- The antibody was purified by affinity chromatography.
- Clone
- SHM14
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product ADAM10 Primary Antibody
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anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 420-641) antibody
ADAM10 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) antibodyADAM10 Reactivity: Human ELISA, IHC, FACS Host: Mouse Monoclonal 6C3C7 unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 400-414), (Extracellular), (N-Term) antibodyADAM10 Reactivity: Human, Rat, Mouse WB, IHC, FACS, LCI Host: Rabbit Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) antibodyADAM10 Reactivity: Human WB, FACS, IP, IHC (p), IHC (fro) Host: Mouse Monoclonal 11G2 unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 501-600) antibodyADAM10 Reactivity: Human, Rat, Mouse WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) antibody (PE)ADAM10 Reactivity: Human FACS Host: Mouse Monoclonal 11G2 PE
anti-ADAM Metallopeptidase Domain 10 (ADAM10) antibodyADAM10 Reactivity: Human WB, IF, ICC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 732-748) antibodyADAM10 Reactivity: Human WB, IHC, ICC Host: Rabbit Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 214-500) antibodyADAM10 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 218-445) antibodyADAM10 Reactivity: Rat WB, IHC, ICC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))
- Alternative Name
- CD156c (ADAM10 Products)
- Background
- CD156c, also known as a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), is a 748 amino acid type I membrane glycoprotein ubiquitously expressed on most cell types. It consists of multiple functional domains, including a N-terminal prodomain, catalytic domain, cysteine-rich domain, transmembranous domain, and cytoplasmic domain. It is secreted as a precursor protein and becomes as the activate/mature form through removing the ADAM10 prodomain by proprotein convertase 7 and furin. ADAM10 functions as metalloproteinase to cleave several molecules including Notch, pro-TNF-α, amyloid precursor protein, myelin basic protein, and type IV collagen. It mediates the release of several cell adhesion molecules such as vascular endothelial cadherin or L-selectin to regulate endothelial permeability and leukocyte transmigration. Dysregulation of ADAM activity may contribute to the pathogenesis of vascular diseases.
- Pathways
- Notch Signaling, EGFR Signaling Pathway
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