CLEC4A antibody (PE)

Catalog No. ABIN2662615

Product Details anti-CLEC4A Antibody (PE)

Target: CLEC4A (C-Type Lectin Domain Family 4, Member A (CLEC4A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CLEC4A antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Clone: 9E8

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CLEC4A

Target: CLEC4A (C-Type Lectin Domain Family 4, Member A (CLEC4A))

Alternative Name: CD367 (CLEC4A Products)

Background: CD367 (CLEC4A), also known as lectin-like immunoreceptor (LLIR) and dendritic cell immunoreceptor (DCIR), is a type II transmembrane protein belonging to C-type lectin domain family, and was previously designated as CLECSF6. It contains one carbohydrate recognition domain in its C-terminal extracellular domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain. CLEC4A is mainly expressed on monocytes, macrophages, dendritic cells, neutrophils, and B cells. It is also found on the surface of CD4+ T cells in rheumatoid arthritis (RA) patients. CLEC4A has been reported to function as a receptor for HIV, cross-present and cross-prime human CD8+ T cells. It might also function as a negative player by recruiting the SHP-1 or/and SHP-2 phosphotase through its immunoreceptor tyrosine-based inhibitory motif (ITIM).