SMO antibody

Catalog No. ABIN4620362

Product Details anti-SMO Antibody

Target: SMO (Smoothened Homolog (Drosophila) (SMO))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMO antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects SMO (Smoothened Homolog).

Purification: Affinity chromatography

Immunogen: Synthetic peptide derived from the human SMO protein

Isotype: IgG

Application Details

Application Notes: Western blot (1: 400 starting dilution). Positive control: Brain.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Target Details for SMO

Target: SMO (Smoothened Homolog (Drosophila) (SMO))

Alternative Name: SMO (SMO Products)

Background: SMO is a G protein-coupled receptor (GPCR) that putatively associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. The binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). In basal cell carcinoma there are two somatic mutations SMO, D473-> H473 and R562 ->Q562.Synonyms: Gx protein, SMOH, Smoothened homolog

Gene ID: 6608

NCBI Accession: NP_005622

UniProt: Q99835

Pathways: Hedgehog Signaling