Sphingomyelin Synthase 2 antibody

Catalog No. ABIN4620351

Product Details anti-Sphingomyelin Synthase 2 Antibody

Target: Sphingomyelin Synthase 2 (SGMS2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sphingomyelin Synthase 2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects Sphingomyelin Synthase 2.

Purification: Antigen Immunoaffinity Chromatography

Immunogen: Synthetic peptide derived from the Human Sphingomyelin Synthase 2 protein

Isotype: IgG

Application Details

Application Notes: Western Blot: 1/400 as starting dilution. Immunohistochemistry: 1/400 as starting dilution. Positive control: Brain, heart, kidney, liver, muscle and stomach.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Sphingomyelin Synthase 2

Target: Sphingomyelin Synthase 2 (SGMS2)

Alternative Name: SGMS2 (SGMS2 Products)

Background: Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine and then onto ceramide. This also yields diacylglycerol as a side product. The reaction is catalysed by SM synthase, an important enzyme in the regulation of diacylglycerol and ceramide as anti- and proapoptotic stimuli. SM synthesis occurs in the lumen of the Golgi as well as on or at the cell surface. It is uncertain which SM enzyme forms are present at these differnet cellular locations. Human, mouse and Caenorhabditis elegans genomes each contain at least two different SM synthase (SMS) genes. Human SMS1 is localised to the Golgi, SMS2 resides primarily at the plasma membrane.Synonyms: SMS2, Sphingomyelin synthase 2

Gene ID: 166929

NCBI Accession: NP_001129729

UniProt: Q8NHU3