LY86 antibody (Middle Region)

Catalog No. ABIN265132

Product Details anti-LY86 Antibody

Target: LY86 (Lymphocyte Antigen 86 (LY86))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LY86 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to MD-1.

Purification: Purified

Immunogen: Rabbit polyclonal MD-1 antibody was raised against a 15 amino acid peptide from near the center of human MD-1.

Isotype: IgG

Application Details

Application Notes: Western Blot: 1 - 2 μg/mL. May cooperate with CD180 and TLR4 to mediate the innate immune response to bacteriallipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cellsurface expression. Highly expressed in B-cells, monocytes and tonsil.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for LY86

Target: LY86 (Lymphocyte Antigen 86 (LY86))

Alternative Name: LY86 / MD-1 (LY86 Products)

Synonyms: MD-1 antibody, MMD-1 antibody, dJ80N2.1 antibody, MD1 antibody, LY86 antibody, lymphocyte antigen 86 antibody, LY86 antibody, Ly86 antibody

Background: Toll-like receptors (TLRs) are evolutionarily conserved patternrecognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD-1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.Synonyms: Lymphocyte antigen 86, MD1

Gene ID: 9450

NCBI Accession: NP_004262

UniProt: O95711

Pathways: Toll-Like Receptors Cascades