PPAP2B antibody

Catalog No. ABIN4620345

Product Details anti-PPAP2B Antibody

Target: PPAP2B (Phosphatidic Acid Phosphatase Type 2B (PPAP2B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPAP2B antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to Phosphatidic Acid Phosphatase 2B .

Purification: Affinity Purified

Immunogen: Synthetic peptide derived from the phosphatidic acid phosphatase 2B protein

Isotype: IgG

Application Details

Application Notes: Western Blot. Enzyme Immunoassay.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Ship on dry ice. Store (in aliquots) at -20 °C to -70 °C.

Target Details for PPAP2B

Target: PPAP2B (Phosphatidic Acid Phosphatase Type 2B (PPAP2B))

Alternative Name: PPAP2B / LPP3 (PPAP2B Products)

Synonyms: Dri42 antibody, LPP3 antibody, PAP2B antibody, VCIP antibody, 1110003O22Rik antibody, 2610002D05Rik antibody, AV025606 antibody, D4Bwg0538e antibody, D4Bwg1535e antibody, Lpp3 antibody, Ppab2b antibody, dri42 antibody, lpp3 antibody, pap2b antibody, ppap2bb antibody, vcip antibody, ppap2b antibody, ppap2ba antibody, PPAP2B antibody, si:dkey-19f4.1 antibody, phospholipid phosphatase 3 antibody, phospholipid phosphatase 3 L homeolog antibody, phospholipid phosphatase 3 S homeolog antibody, PLPP3 antibody, Plpp3 antibody, plpp3.L antibody, plpp3.S antibody, plpp3 antibody

Background: Vascular endothelial growth factor and type I collagen inducible protein (VCIP), also known as phosphatidic acid phosphatase 2b (PAP2b), was originally identified in a functional assay of angiogenesis. VCIP/PAP2b exhibits an Arg - Gly - Asp (RGD) cell adhesion sequence. Immunoprecipitation and fluorescence-activated cell sorting analyses demonstrated that VCIP-RGD is exposed to the outside of the cell surface. Retroviral transduction of VCIP can induce cell aggregation and cell-cell interactions, modestly increase p120 catenin expression and promote activation of the Fak, Akt and GSK3ß protein kinases. Expression of VCIP promoted adhesion, spreading and tyrosine phosphorylation of Fak, Shc, Cas and paxillin in endothelial cells. PAP2b/VCIP is expressed in close proximity to vascular endothelial growth factor, von Willebrand factor and {alpha}vbeta3 integrin in tumor vasculatures.Synonyms: Lipid phosphate phosphohydrolase 3, PAP2-beta, PAP2B, Phosphatidate phosphohydrolase type 2b, Phosphatidic acid phosphatase 2b, VCIP, Vascular endothelial growth factor and type I collagen-inducible protein

Gene ID: 8613

NCBI Accession: NP_003704

UniProt: O14495