PPAP2C antibody

Catalog No. ABIN265044

This anti-PPAP2C antibody is a Rabbit Polyclonal antibody detecting PPAP2C in WB. Suitable for Human.

Quick Overview for PPAP2C antibody (ABIN265044)

Target: PPAP2C (Phosphatidic Acid Phosphatase Type 2C (PPAP2C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPAP2C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PPAP2C Antibody

Specificity: This antibody reacts to Lyosphospholipid Phosphatase (LPP) 2.

Purification: Purified

Immunogen: Unique peptide derived from the human lysophospholipid phosphatase 2 protein.

Isotype: IgG

Application Details

Application Notes: Western Blot: 10 - 15 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for PPAP2C

Target: PPAP2C (Phosphatidic Acid Phosphatase Type 2C (PPAP2C))

Alternative Name: PPAP2C / LPP2

Background: Phosphatidic acid phosphatase type 2 (PAP2) was originally identified as a plasma membrane enzyme that catalyses the dephosphorylation of the putative second messenger, phosphatidic acid (PA) to diacylglycerol (DG) [1]. Subsequently, multiple isoforms of PAP2 were cloned [2-5]. It was found that these enzymes dephosphorylate a number of lipid phosphates in vitro other than PA, including the potent bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Therefore, they have been renamed lipid phosphate phosphatases (LPPs). Currently, there are four members of this family called LPP1, LPP1a, LPP2 and LPP3 [6]. S1P [7] and LPA [8] regulate the proliferation, differentiation, apoptosis and migration of cells by binding to a family of G protein-coupled receptors. Thus, EDG1/S1P1, EDG3/S1P3, EDG5/S1P2/AGR16/H218, EDG6/S1P4 and EDG8/S1P5/nrg-1 are high affinity S1P receptors [7] whereas EDG2/LPA1, EDG4/LPA2 and EDG7/LPA3 have high affinity for LPA [8]. Recently, the over-expression of LPP1 was shown to limit LPA-stimulated signalling in Rat2 fibroblasts [9] and LPA-stimulated DNA synthesis in HEK 293 cells [10]. Similarly, over-expression of LPP1, LPP1a and LPP2 attenuate S1P-signalling to the p42/p44 mitogen activated protein kinase cascade [11].Synonyms: Lipid phosphate phosphohydrolase 2, PAP2-gamma, Phosphatidate phosphohydrolase type 2c, Phosphatidic acid phosphatase 2c

Gene ID: 8612

NCBI Accession: NP_003703

UniProt: O43688