ADRA2B antibody

Catalog No. ABIN264463

Product Details anti-ADRA2B Antibody

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Reactivity: Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This ADRA2B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Characteristics: Synonyms: ADRA2B, ADRA2L1, ADRA2RL1, Alpha-2B adrenoreceptor, Alpha-2B adrenoceptor

Purification: Purified

Immunogen: Antibody raised to synthetic peptide internal sequence corresponding to the thirdintracellular loop of rat alpha 2b adrenergic receptor.

Clone: 5G10

Isotype: IgG1

Application Details

Application Notes: Western blot (1-5 μg/mL). Immunohistochemistry. Positive Control/Tissue Expression: MDCK cells transfected with rat alpha2B adrenergicreceptors.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.08 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Expiry Date: 12 months

Target Details for ADRA2B

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Alternative Name: alpha-2B Adrenergic Receptor (ADRA2B Products)

Background: The rat alpha 2b adrenergic receptor is a G protein coupled receptor which acts through Gi2 and is responsible for Cellular communication and signal transduction. These receptors are linked to pertussis toxin-sensitive G proteins. Agonist binding leads to inhibition of adenylyl cyclase, inhibition of Ca(2+) channels and activation of K(+) channels. Recently, three distinct subtypes of alpha(2)-AR were described, alpha(2A)-AR, alpha(2B)-AR and alpha(2C)-AR. At present, it is unknown which of these alpha(2)-AR subtype(s) may regulate insulin secretion.Synonyms: ADRA2B, ADRA2L1, ADRA2RL1, Alpha-2B adrenoceptor, Alpha-2B adrenoreceptor

Gene ID: 24174

UniProt: P19328

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process