CD8 alpha antibody
-
- Target See all CD8 alpha (CD8A) Antibodies
- CD8 alpha (CD8A) (CD8a Molecule (CD8A))
-
Reactivity
- Mouse
-
Host
- Rat
-
Clonality
- Monoclonal
-
Conjugate
- This CD8 alpha antibody is un-conjugated
-
Application
- Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Functional Studies (Func)
- Specificity
- The 53-6.7 monoclonal antibody specifically reacts with Ly-2, the 38 kDa alpha chain, and with Lyt-2, the 34 kDa alpha' chain, of the mouse CD8 antigen.
- Purification
- The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
- Clone
- 53-6-7
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product CD8A Primary Antibody
-
anti-CD8a Molecule (CD8A) (AA 22-235) antibody
CD8A Reactivity: Human FACS, WB, ELISA Host: Mouse Monoclonal 8H8A8 unconjugated
anti-CD8a Molecule (CD8A) antibodyCD8A Reactivity: Mouse FACS, IP, IHC (fro), IHC (p), ICC, Func Host: Rat Monoclonal 53-6-7 unconjugated
anti-CD8a Molecule (CD8A) antibodyCD8A Reactivity: Mouse FACS, IP, IHC (fro), IHC (p), ICC Host: Rat Monoclonal 53-6-7 unconjugated
anti-CD8a Molecule (CD8A) antibody (FITC)CD8A Reactivity: Mouse FACS Host: Rat Monoclonal 53-6-7 FITC
anti-CD8a Molecule (CD8A) antibody (PE)CD8A Reactivity: Mouse FACS Host: Rat Monoclonal 53-6-7 PE
anti-CD8a Molecule (CD8A) (AA 51-150) antibodyCD8A Reactivity: Human, Rat, Chicken FACS, WB, ELISA, IHC (fro), IHC (p), IF (p), IF (cc) Host: Rabbit Polyclonal unconjugated
anti-CD8a Molecule (CD8A) antibodyCD8A Reactivity: Human IHC, WB, IP, ELISA Host: Rabbit Monoclonal 2F2 unconjugated Recombinant Antibody
anti-CD8a Molecule (CD8A) (AA 22-182) antibodyCD8A Reactivity: Human FACS, ELISA Host: Mouse Monoclonal 6A9A5 unconjugated
anti-CD8a Molecule (CD8A) antibodyCD8A Reactivity: Human IHC, StM, ISt Host: Mouse Monoclonal C8-468 unconjugated
anti-CD8a Molecule (CD8A) (AA 28-196) antibodyCD8A Reactivity: Mouse, Rat FACS, IHC, WB, ELISA, ICC Host: Rabbit Polyclonal unconjugated
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.
- Storage
- 4 °C
- Storage Comment
- The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
-
- Target
- CD8 alpha (CD8A) (CD8a Molecule (CD8A))
- Alternative Name
- CD8a (CD8A Products)
- Background
- The 53-6.7 monoclonal antibody specifically reacts with Ly-2, the 38 kDa alpha chain, and with Lyt-2, the 34 kDa alpha' chain, of the mouse CD8 antigen. The alpha' chain is the truncated form of alpha chain, encoded by the same CD8a gene. In CD8a, the alpha and alpha' chains form heterodimers with CD8b (the beta chains) or homodimers (alpha-alpha), which occur as receptors on the surface of the majority of thymocytes. A subpopulation of mature T lymphocytes expresses the CD8 alpha beta (alpha beta TCR T cells), and a subpopulation of intestinal intraepithelial lymphocytes and dendritic cells express CD8a without CD8b.CD8 interacts with the mouse major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells. Its function seems to be to attenuate the CD8-mediated signal for the stimulation of intrathymic T-cell maturation.The 53-6.7 antibody is useful for depleting CD8+ peripheral T lymphocytes. It cross reacts with the alpha- and alpha'-like polypeptides on some thymic and peripheral lymphocytes.
- Gene ID
- 12525
- UniProt
- P01731
- Pathways
- TCR Signaling
-
