L-Selectin antibody (FITC)
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- Target See all L-Selectin (SELL) Antibodies
- L-Selectin (SELL) (Selectin L (SELL))
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Reactivity
- Rat
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Host
- Rat
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Clonality
- Monoclonal
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Conjugate
- This L-Selectin antibody is conjugated to FITC
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Application
- Flow Cytometry (FACS)
- Specificity
- The MEL-14 monoclonal antibody specifically reacts with L- selectin (CD62L), a receptor with lectin-like and Epidermal Growth Factor-like domains.
- Purification
- The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
- Clone
- MEL-14
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product SELL Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.
- Storage
- 4 °C
- Storage Comment
- The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
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- Target
- L-Selectin (SELL) (Selectin L (SELL))
- Alternative Name
- CD62L (SELL Products)
- Target Type
- Chemical
- Background
- The MEL-14 monoclonal antibody specifically reacts with L- selectin (CD62L), a receptor with lectin-like and Epidermal Growth Factor-like domains. The weight of the CD62L molecules depend on their origin, 74 kDa on lymphocytes or 95 kDa on neutrophils. In the mouse organism, CD62L can be expressed by most thymocytes, on subsets of B and T lymphocytes, monocytes, eosinophils, and neutrophils. The L-selectin binds sulfated, fucosylated, and glycosylated glycoproteins (MadCAM-1, GLYCAM-1, and CD 34). It mediates the migration of lymphocytes to the site of inflammation and their return to the peripheral lymphoid tissues and to the HEV (high endothelial venules). In vitro, L-selectin inhibits this binding and the lymphocyte extravasation into peripheral lymph nodes. After cell activation, it is quickly shed by neutrophils and lymphocytes.
- Gene ID
- 20343
- UniProt
- P18337
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