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CD3 antibody

CD3 Reactivity: Mouse FACS, IP, IHC, Func Host: Rat Monoclonal 17A2 unconjugated

Catalog No. ABIN2567480

Datasheet as PDF

Target See all CD3 Antibodies

CD3
Reactivity
177

98

24

20

17

10

8

8

7

7

5

3

2

1
Mouse
Host
210

47

20

13

9

1
Rat
Compatible Secondaries
Clonality
289

6

1
Monoclonal
Conjugate
93

39

32

23

23

11

8

6

5

5

5

4

4

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This CD3 antibody is un-conjugated
Application
274

81

58

52

45

38

32

22

9

8

7

6

4

3

2

2

2

2

2

2

2

2

1

1
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), Functional Studies (Func)

Specificity

The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation.

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/μg of the protein.

Clone

17A2

Isotype

IgG2b kappa

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CD3 Reactivity: Human FACS, IP Host: Mouse Monoclonal MEM-57 Biotin

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CD3 Reactivity: Human, Non-Human Primate FACS Host: Mouse Monoclonal UCHT1 PerCP

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CD3 Reactivity: Human FACS Host: Mouse Monoclonal MEM-57 PerCP

anti-CD3 (CD3) antibody (APC)
CD3 Reactivity: Human FACS Host: Mouse Monoclonal MEM-57 APC

Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Liquid

Concentration

2 mg/mL

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Storage

4 °C

Storage Comment

The product should be stored undiluted at 4°C. Do not freeze.
Target

CD3

Alternative Name

CD3 (CD3 Products)

Background

The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains γ, δ, and ε subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 ε chain.

Gene ID

12501

UniProt

P22646

Pathways

TCR Signaling, Ubiquitin Proteasome Pathway