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CD11b antibody (Activation Domain)

ITGAM Reactivity: Human FACS, Func Host: Mouse Monoclonal CBRM1-5 unconjugated

Catalog No. ABIN2567135

Datasheet as PDF

Target See all CD11b (ITGAM) Antibodies

CD11b (ITGAM) (Integrin alpha M (ITGAM))
Binding Specificity
16

14

8

6

6

5

5

5

4

3

3

3

3

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Activation Domain
Reactivity
252

166

66

34

20

19

17

14

11

10

7

4

4

2

2

1
Human
Host
138

105

105

2

1

1
Mouse
Compatible Secondaries
Clonality
254

94

2
Monoclonal
Conjugate
118

39

30

27

20

9

7

7

5

5

5

5

4

4

3

3

3

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
This CD11b antibody is un-conjugated
Application
264

83

80

78

60

45

36

24

22

19

14

14

7

6

5

5

4

4

3

2

2

1

1

1
Flow Cytometry (FACS), Functional Studies (Func)

Specificity

The CBRM1/5 monoclonal antibody binds with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin β2) a complex known as Mac-1.

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/μg of the protein.

Clone

CBRM1-5

Isotype

IgG1 kappa

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anti-Integrin alpha M (ITGAM) (AA 145-340) antibody
ITGAM Reactivity: Human IHC, WB, IF Host: Rabbit Polyclonal unconjugated

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ITGAM Reactivity: Human, Mouse, Rat FACS, WB, IHC (fro), ELISA, IHC (p), IF (cc), IF (p) Host: Rabbit Polyclonal unconjugated

anti-Integrin alpha M (ITGAM) (AA 31-160) antibody
ITGAM Reactivity: Rat IHC, WB, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Integrin alpha M (ITGAM) antibody (FITC)
ITGAM Reactivity: Human FACS Host: Mouse Monoclonal MEM-174 FITC

anti-Integrin alpha M (ITGAM) antibody (Biotin)
ITGAM Reactivity: Human FACS, IP Host: Mouse Monoclonal MEM-174 Biotin

anti-Integrin alpha M (ITGAM) antibody (PE)
ITGAM Reactivity: Human FACS Host: Mouse Monoclonal MEM-174 PE

anti-Integrin alpha M (ITGAM) (AA 623-728) antibody
ITGAM Reactivity: Human ELISA, ICC Host: Mouse Monoclonal 3A10H5 unconjugated

anti-Integrin alpha M (ITGAM) (AA 941-1074) antibody
ITGAM Reactivity: Human IHC, WB, StM Host: Mouse Monoclonal ITGAM-3340 unconjugated

Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Storage

4 °C

Storage Comment

The product should be stored undiluted at 4°C. Do not freeze.
Target

CD11b (ITGAM) (Integrin alpha M (ITGAM))

Alternative Name

CD11b (ITGAM Products)

Background

The CBRM1/5 monoclonal antibody binds with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin β2) a complex known as Mac-1. CD11b is expressed on the surface of activated lymphocytes, a subset of natural killer cells, granulocytes, and monocytes. It functions as a receptor in cell-cell and cell-matrix interactions and as a receptor for iC3b, ICAM-1, ICAM-2, and ICAM-3 intercellular adhesion molecules. The CBRM1/5 specifically reacts with the activation-specific epitope of the Mac-1 Molecule, in the I domain on the alpha chain near the ligand binding site. The antibody has been reported to inhibit the cellular adhesion mediated by Mac-1.

Gene ID

3684

UniProt

P11215

Pathways

Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation