FCGR1A antibody (PE)

Catalog No. ABIN2472294

Product Details anti-FCGR1A Antibody (PE)

Target: FCGR1A (Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))

Reactivity: Human, Baboon, Rhesus Monkey, Cynomolgus

Host: Mouse

Clonality: Monoclonal

Conjugate: This FCGR1A antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: Mouse anti Human CD64 antibody, clone 10.1 recognizes the human CD64 cell surface antigen, a ~75 kDa glycoprotein expressed by monocytes. The antigen acts as a high affinity receptor for human IgG, and is also known as FcRI.

Cross-Reactivity: Baboon, Cynomolgus, Rhesus Monkey

Characteristics: Purified IgG conjugated to R. Phycoerythrin (RPE)

Purification: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogen: Human monocytes

Clone: 10-1

Isotype: IgG1

Application Details

Application Notes: Mouse anti Human CD64 antibody, clone 10.1 blocks binding of immunoglobulin to FcRI.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with distilled water

Buffer: Phosphate buffered saline, 0.09% Sodium Azide,1% Bovine Serum Albumin, 5% Sucrose

Handling Advice: DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Storage: 4 °C

Storage Comment: Prior to reconstitution store at +4°C. Following reconstitution store at +4°C.

References for anti-FCGR1A antibody (PE) (ABIN2472294)

Beekman, Bakema, van de Winkel, Leusen: "Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 28, pp. 10392-7, (2004) (PubMed).

Yoshino, Ami, Terao, Tashiro, Honda: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, (2000) (PubMed).

Target Details for FCGR1A

Target: FCGR1A (Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))

Alternative Name: CD64 (FCGR1A Products)

Background: Synonyms: FcRI

Gene ID: 2209

UniProt: P12314

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process