FAS antibody

Catalog No. ABIN2470748

Product Details anti-FAS Antibody

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FAS antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC)

Purification: Ion Exchange Chromatography

Immunogen: FAS monoclonal antibody was raised against HUT - 78 human T cell lymphoma cell line (Human).

Clone: LT95

Isotype: IgG1

Application Details

Application Notes: FAS antibody can be used in Western Blot at 1 - 2 μg/mL, immunohistochemistry starting at 10 μg/mL, and immunoprecipitation starting at 300 - 500 g/1E6 cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 20 mM Tris/HCl, 15 mM sodium azide, approx., pH 7.4.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store FAS antibody at 4 °C or -20 °C.

Target Details for FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Alternative Name: FAS (FAS Products)

Background: Reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule.

Gene ID: 355

UniProt: P25445

Pathways: p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity