C3 antibody
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- Target See all C3 Antibodies
- C3 (Complement Component 3 (C3))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This C3 antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
- Specificity
- Specific for human complement component 3d (C3d) neoantigen, a 33kD polypeptide fragment generated over the course of complement activation in which where complement 3 (C3) convertases cleave C3 to C3b, which is further degraded into iC3b and C3dg/C3d. C3d is involved in the regulation of many aspects of the immune response, including antigen processing and presentation. The C3d/antigen complex mediates B cell activation by simultaneously binding antigen-specific surface bound immunoglobulin and CD21, lowering the complement activation threshold. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.
- Purification
- Protein A purified
- Immunogen
- Purified human C3d (neoantigen).
- Isotype
- IgG1
- Top Product
- Discover our top product C3 Primary Antibody
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anti-Complement Component 3 (C3) (AA 1000-1326) antibody
C3 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 1551-1663) antibodyC3 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (fro), IF (p), IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 1534-1644) antibodyC3 Reactivity: Human WB, ELISA, IHC (p) Host: Mouse Monoclonal 5F9 unconjugated
anti-Complement Component 3 (C3) (C-Term) antibodyC3 Reactivity: Human WB, IP, IF, ICC, IHC (p), ISub Host: Rabbit Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 23-300) antibodyC3 Reactivity: Pig WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 965-1303) antibodyC3 Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 1534-1645) antibodyC3 Reactivity: Human WB, ELISA, IHC, IHC (p) Host: Mouse Monoclonal 5F9 unconjugated
anti-Complement Component 3 (C3) antibodyC3 Reactivity: Mouse WB, IP, FACS, IF, IA Host: Rat Monoclonal 11H9 unconjugated
anti-Complement Component 3 (C3) (AA 966-1313) antibodyC3 Reactivity: Rat WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 1534-1644) antibodyC3 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Target Species of Antibody: Human
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Borate buffered saline, 0.1 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C,-20 °C
- Storage Comment
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- Target
- C3 (Complement Component 3 (C3))
- Alternative Name
- Complement C3 (C3 Products)
- Background
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Name/Gene ID: C3
Synonyms: C3, AHUS5, ARMD9, Complement component C3, CPAMD1, Complement C3, ASP, Complement component 3 - Gene ID
- 718
- Pathways
- Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling
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