C1q antibody

Catalog No. ABIN206655

Product Details anti-C1q Antibody

Target: C1q (Complement Fragment C1q (C1q))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This C1q antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: Recognizes human complement component 1, q subcomponent (C1q), a 156kD secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis.

Purification: Protein A purified

Immunogen: Binds globular head domain of C1q, purified from human plasma.

Clone: 3R9-2

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA, Flo, IHC, IHC-Fr (1:500 - 1:1000)

Usage: Immunohistology: Strong staining was observed in the glomeruli and in some cases the peritubular capillary (potentially clinically significant).

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Borate buffered saline, 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for C1q

Target: C1q (Complement Fragment C1q (C1q))

Alternative Name: Complement C1q (C1q Products)