CD226 antibody

Catalog No. ABIN206458

Product Details anti-CD226 Antibody

Target: CD226

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD226 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Specificity: Recognizes human CD226, a 65kD glycoprotein, also known as DNAM1 (DNAX accessory molecule-1). CD226 is broadly expressed on T-cells, NK cells, platelets, monocytes and a subset of B cells. CD226 is also expressed by a subset of CD3 positive thymocytes. Clone DX11 is reported to inhibit T- and NK cell mediated cytotoxicity against tumor cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells. XXX recommend the use of MCA2257XZ for functional studies.

Purification: Protein G purified

Immunogen: Human cytotoxic T lymphocyte clone.

Type of Immunogen: Cells

Isotype: IgG1

Application Details

Application Notes: Approved: Flo (1:25 - 1:100), IP

Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 1 x 10^6 cells in 100 μL. Method sheets are available on request.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for CD226

Target: CD226

Alternative Name: DNAM-1 / CD226 (CD226 Products)

Background: Name/Gene ID: CD226

Synonyms: CD226, Adhesion glycoprotein, CD226 Molecule, CD226 antigen, DNAM-1, DNAM1, DNAX accessory molecule-1, TLiSA1, PTA1, DNAX accessory molecule 1

Gene ID: 10666

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints